Anti-D4S234E antibody (140-190) {Biotin} (STJ501973)

SKU:
STJ501973-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-D4S234E (140-190) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:150
ICC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Nsg1
Gene ID: 25247
Uniprot ID: NSG1_RAT
Immunogen Region: 140-190
Immunogen: Synthetic peptide taken within amino acid region 140-190 on human Neuron-specific protein family member 1.
Tissue Specificity Widely expressed in brain and spinal cord. Expressed in neurons during maturation and synapse formation.
Function Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome. In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage.
Protein Name Neuronal Vesicle Trafficking-Associated Protein 1
Brain Neuron Cytoplasmic Protein 1/2
Neuron-Enriched Endosomal Protein Of 21 Kda
Neuron-Specific Protein Family Member 1
Cellular Localisation Membrane
Single-Pass Type Ii Membrane Protein
Golgi Apparatus
Trans-Golgi Network Membrane
Endosome Membrane
Cell Projection
Dendrite
Early Endosome Membrane
Late Endosome Membrane
Lysosome Lumen
Recycling Endosome Membrane
Cytoplasmic Vesicle Membrane
Golgi Stack Membrane
Endosome
Multivesicular Body Membrane
Endoplasmic Reticulum Membrane
Endocytosed From The Cell Surface
Thus Enters Into Early Endosomes
Trafficks To Late Endosomes And Degradates In Lysosomes
Endoplasmic Reticulum Targeting Is Essential For Apoptosis
Found In Both Stationary And Motile Endosomes
A Previous Study Supports A Type I Membrane Protein Topology
Alternative Antibody Names Anti-Neuronal Vesicle Trafficking-Associated Protein 1 antibody
Anti-Brain Neuron Cytoplasmic Protein 1/2 antibody
Anti-Neuron-Enriched Endosomal Protein Of 21 Kda antibody
Anti-Neuron-Specific Protein Family Member 1 antibody
Anti-Nsg1 antibody
Anti-Bsmrb antibody

Information sourced from Uniprot.org

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