![Anti-Cytokeratin 8 antibody [SM5164] (STJA0005164)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180214/403657/STJA0005164_1__44230.1738950662.png?c=1 "Anti-Cytokeratin 8 antibody [SM5164] (STJA0005164)")
![Anti-Cytokeratin 8 antibody [SM5164] (STJA0005164)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/180214/403657/STJA0005164_1__44230.1738950662.png?c=1 "Anti-Cytokeratin 8 antibody [SM5164] (STJA0005164)")
Anti-Cytokeratin 8 antibody [SM5164] (STJA0005164)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenSynthesized peptide derived from human Cytokeratin 8
General Information
| Short Description | Mouse monoclonal anti-Cytokeratin 8 for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5164 |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC/IF (H) 1:200-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | KRT8 |
| Gene ID | 3856 |
| Uniprot ID | K2C8_HUMAN |
| Immunogen | Synthesized peptide derived from human Cytokeratin 8 |
Additional Info
| Post Translational Modifications | Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. |
| Function | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
| Protein Name | Keratin - Type Ii Cytoskeletal 8Cytokeratin-8Ck-8Keratin-8K8Type-Ii Keratin Kb8 |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmNucleus Matrix |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 8 antibodyAnti-Cytokeratin-8 antibodyAnti-Ck-8 antibodyAnti-Keratin-8 antibodyAnti-K8 antibodyAnti-Type-Ii Keratin Kb8 antibodyAnti-KRT8 antibodyAnti-CYK8 antibody |
Information sourced from Uniprot.org