Anti-Cytokeratin 8 antibody [2A4] (STJ16100817)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenCytokeratins isolated from cultured pig kidney epithelial cells
General Information
| Short Description | Mouse monoclonal anti-Cytokeratin 8 for use in IHC-F and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2A4 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 100 Mu g/mL |
| Dilution Range | IHC-FWB 1:1000 |
| Formulation | PBS with 1% BSA & 0.1% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | KRT8 |
| Gene ID | 3856 |
| Uniprot ID | K2C8_HUMAN |
| Immunogen | Cytokeratins isolated from cultured pig kidney epithelial cells |
Additional Info
| Tissue Specificity | Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. |
| Post Translational Modifications | Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. |
| Function | Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
| Protein Name | Keratin - Type Ii Cytoskeletal 8Cytokeratin-8Ck-8Keratin-8K8Type-Ii Keratin Kb8 |
| Database Links | Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmNucleus Matrix |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 8 antibodyAnti-Cytokeratin-8 antibodyAnti-Ck-8 antibodyAnti-Keratin-8 antibodyAnti-K8 antibodyAnti-Type-Ii Keratin Kb8 antibodyAnti-KRT8 antibodyAnti-CYK8 antibody |
Information sourced from Uniprot.org