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Anti-Cytokeratin 5 antibody [SM4947] (STJA0004947)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant protein corresponding to Mouse Cytokeratin 5
General Information
| Short Description | Mouse monoclonal anti-Cytokeratin 5 for use in WB, IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM4947 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB (H) 1:1000-1:2000IHC/IF (H) 1:400-1:800 |
| Formulation | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Krt5 |
| Gene ID | 110308 |
| Uniprot ID | K2C5_MOUSE |
| Immunogen | Recombinant protein corresponding to Mouse Cytokeratin 5 |
Additional Info
| Post Translational Modifications | Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle. Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis. CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury. O-glycosylated. |
| Function | Required for the formation of keratin intermediate filaments in the basal epidermis and maintenance of the skin barrier in response to mechanical stress. Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes. |
| Protein Name | Keratin - Type Ii Cytoskeletal 5Cytokeratin-5Ck-5Keratin-5K5Type-Ii Keratin Kb5 |
| Database Links | Reactome: R-MMU-446107Reactome: -MMU-6805567Reactome: -MMU-6809371 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Keratin - Type Ii Cytoskeletal 5 antibodyAnti-Cytokeratin-5 antibodyAnti-Ck-5 antibodyAnti-Keratin-5 antibodyAnti-K5 antibodyAnti-Type-Ii Keratin Kb5 antibodyAnti-Krt5 antibodyAnti-Krt2-5 antibody |
Information sourced from Uniprot.org