![Anti-Cytokeratin 14 antibody [SM5155] (STJA0005155)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/180205/403647/STJA0005155_1__01337.1738950651.png?c=1 "Anti-Cytokeratin 14 antibody [SM5155] (STJA0005155)")
![Anti-Cytokeratin 14 antibody [SM5155] (STJA0005155)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/180205/403647/STJA0005155_1__01337.1738950651.png?c=1 "Anti-Cytokeratin 14 antibody [SM5155] (STJA0005155)")
Anti-Cytokeratin 14 antibody [SM5155] (STJA0005155)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenSynthesized peptide derived from human Cytokeratin 14
General Information
| Short Description | Mouse monoclonal anti-Cytokeratin 14 for use in IHC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM5155 |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC/IF (H) 1:200-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | KRT14 |
| Gene ID | 3861 |
| Uniprot ID | K1C14_HUMAN |
| Immunogen | Synthesized peptide derived from human Cytokeratin 14 |
Additional Info
| Post Translational Modifications | A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus. Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex. |
| Function | The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. |
| Protein Name | Keratin - Type I Cytoskeletal 14Cytokeratin-14Ck-14Keratin-14K14 |
| Database Links | Reactome: R-HSA-446107Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | CytoplasmNucleusExpressed In Both As A Filamentous Pattern |
| Alternative Antibody Names | Anti-Keratin - Type I Cytoskeletal 14 antibodyAnti-Cytokeratin-14 antibodyAnti-Ck-14 antibodyAnti-Keratin-14 antibodyAnti-K14 antibodyAnti-KRT14 antibody |
Information sourced from Uniprot.org