| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP3A5 (233-502) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP3A5 |
| Gene ID: |
1577 |
| Uniprot ID: |
CP3A5_HUMAN |
| Immunogen Region: |
233-502 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 233-502 of human CYP3A5 (NP_000768.1). |
| Immunogen Sequence: |
FEALNVSLFPKDTINFLSKS VNRMKKSRLNDKQKHRLDFL QLMIDSQNSKETESHKALSD LELAAQSIIFIFAGYETTSS VLSFTLYELATHPDVQQKLQ KEIDAVLPNKAPPTYDAVVQ MEYLDMVVNETLRLFPVAIR LERTCKKDVEINGVFIPKGS MVVIPTYALHHDPKYWTEPE EFRPERFSKKKDSIDPYIYT PFGTGPRNCIGMRFALMNMK LALIRVLQNFSFKPCKETQ |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2. Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione. Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance. Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine. |
| Protein Name | Cytochrome P450 3a5Cypiiia5Cytochrome P450-Pcn3 |
| Database Links | Reactome: R-HSA-211981Reactome: R-HSA-5423646 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 3a5 antibodyAnti-Cypiiia5 antibodyAnti-Cytochrome P450-Pcn3 antibodyAnti-CYP3A5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
