| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP2E1 (234-493) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP2E1 |
| Gene ID: |
1571 |
| Uniprot ID: |
CP2E1_HUMAN |
| Immunogen Region: |
234-493 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 234-493 of human CYP2E1 (NP_000764.1). |
| Immunogen Sequence: |
KVIKNVAEVKEYVSERVKEH HQSLDPNCPRDLTDCLLVEM EKEKHSAERLYTMDGITVTV ADLFFAGTETTSTTLRYGLL ILMKYPEIEEKLHEEIDRVI GPSRIPAIKDRQEMPYMDAV VHEIQRFITLVPSNLPHEAT RDTIFRGYLIPKGTVVVPTL DSVLYDNQEFPDPEKFKPEH FLNENGKFKYSDYFKPFSTG KRVCAGEGLARMELFLLLCA ILQHFNLKPLVDPKDIDLS |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics (Probable). |
| Protein Name | Cytochrome P450 2e14-Nitrophenol 2-HydroxylaseCypiie1Cytochrome P450-J |
| Database Links | Reactome: R-HSA-211981Reactome: R-HSA-211999Reactome: R-HSA-9027307Reactome: R-HSA-9749641Reactome: R-HSA-9753281 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome MembraneMitochondrion Inner MembranePost-Translationally Targeted To MitochondriaTomm70 Is Required For The Translocation Across The Mitochondrial Outer MembraneAfter Translocation Into The MatrixAssociates With The Inner Membrane As A Membrane Extrinsic Protein |
| Alternative Antibody Names | Anti-Cytochrome P450 2e1 antibodyAnti-4-Nitrophenol 2-Hydroxylase antibodyAnti-Cypiie1 antibodyAnti-Cytochrome P450-J antibodyAnti-CYP2E1 antibodyAnti-CYP2E antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of NIH-3T3 cells using [KO Validated] Fascin/Fascin/FSCN1 Rabbit polyclonal antibody (STJ23712) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/99661/384925/STJ23712_1__28840.1713153730.jpg?c=1 "Immunofluorescence analysis of NIH-3T3 cells using [KO Validated] Fascin/Fascin/FSCN1 Rabbit polyclonal antibody (STJ23712) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.")