• Western blot analysis of 293 cells using CYP2B6 Polyclonal Antibody

Anti-CYP2B6 antibody (Internal) (STJ92573)

SKU:
STJ92573

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cytochrome P450 2B6 (Internal) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CYP2B6
Gene ID: 1555
Uniprot ID: CP2B6_HUMAN
Immunogen Region: Internal
Specificity: CYP2B6 Polyclonal Antibody detects endogenous levels of CYP2B6 protein.
Immunogen: Synthesized peptide derived from the Internal region of human CYP2B6.
Post Translational Modifications Phosphorylation is accompanied by a decrease in enzyme activity.
Function A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling. Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2. Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs. Acts as a 1,4-cineole 2-exo-monooxygenase. Allele 2B6*9: Has low affinity for anandamide and can only produce 11,12 EpETrE-EAs.
Protein Name Cytochrome P450 2b6
1 -4-Cineole 2-Exo-Monooxygenase
Cypiib6
Cytochrome P450 Iib1
Database Links Reactome: R-HSA-211935
Reactome: R-HSA-211945
Reactome: R-HSA-211981
Reactome: R-HSA-211999
Cellular Localisation Endoplasmic Reticulum Membrane
Peripheral Membrane Protein
Microsome Membrane
Alternative Antibody Names Anti-Cytochrome P450 2b6 antibody
Anti-1 -4-Cineole 2-Exo-Monooxygenase antibody
Anti-Cypiib6 antibody
Anti-Cytochrome P450 Iib1 antibody
Anti-CYP2B6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance