| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC/ICC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-CYP26A1 (Internal) is suitable for use in ELISA, Immunohistochemistry and Immunocytochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-3.75µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CYP26A1 |
| Gene ID: |
1592 |
| Uniprot ID: |
CP26A_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_000774.2; NP_476498.1 |
| Specificity: |
This antibody is expected to recognize both reported isoforms (NP_000774.2; NP_476498.1) |
| Immunogen Sequence: |
NLPARFTHFHGE |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals. RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (Probable). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling. Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (Probable). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA. May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid. |
| Protein Name | Cytochrome P450 26a1Cyp26a1Cytochrome P450 Retinoic Acid-Inactivating 1Cytochrome P450raiHp450raiRetinoic Acid 4-HydroxylaseRetinoic Acid-Metabolizing Cytochrome |
| Database Links | Reactome: R-HSA-211916Reactome: R-HSA-5365859 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 26a1 antibodyAnti-Cyp26a1 antibodyAnti-Cytochrome P450 Retinoic Acid-Inactivating 1 antibodyAnti-Cytochrome P450rai antibodyAnti-Hp450rai antibodyAnti-Retinoic Acid 4-Hydroxylase antibodyAnti-Retinoic Acid-Metabolizing Cytochrome antibodyAnti-CYP26A1 antibodyAnti-CYP26 antibodyAnti-P450RAI1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
