Anti-Cyclophilin F/PPIF antibody (30-207aa) [AT1F5] (STJA0041560)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant human PPIF (30-207aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-Cyclophilin F/PPIF (30-207aa) for use in ELISA, WB, ICC, IF and IHC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF/IHC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT1F5 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPIF |
| Gene ID | 10105 |
| Uniprot ID | PPIF_HUMAN |
| Accession Number | NP_005720 |
| Immunogen | Recombinant human PPIF (30-207aa) purified from E. coli |
| Immunogen Region | 30-207aa |
Additional Info
| Post Translational Modifications | Acetylated at Lys-167.deacetylated at Lys-167 by SIRT3. |
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis.the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase F - MitochondrialPpiase FCyclophilin DCyp-DCypdCyclophilin FMitochondrial CyclophilinCyp-MRotamase F |
| Database Links | |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase F - Mitochondrial antibodyAnti-Ppiase F antibodyAnti-Cyclophilin D antibodyAnti-Cyp-D antibodyAnti-Cypd antibodyAnti-Cyclophilin F antibodyAnti-Mitochondrial Cyclophilin antibodyAnti-Cyp-M antibodyAnti-Rotamase F antibodyAnti-PPIF antibodyAnti-CYP3 antibody |
Information sourced from Uniprot.org