Anti-Cyclophilin 40/PPID antibody (1-370aa) [AT1B8] (STJA0041846)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant human PPID (1-370aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-Cyclophilin 40/PPID (1-370aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT1B8 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PPID |
| Gene ID | 5481 |
| Uniprot ID | PPID_HUMAN |
| Accession Number | NP_005029 |
| Immunogen | Recombinant human PPID (1-370aa) purified from E. coli |
| Immunogen Region | 1-370aa |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer.the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase DPpiase D40 Kda Peptidyl-Prolyl Cis-Trans IsomeraseCyclophilin-40Cyp-40Cyclophilin-Related ProteinRotamase D |
| Database Links | Reactome: R-HSA-8939211 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasm |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase D antibodyAnti-Ppiase D antibodyAnti-40 Kda Peptidyl-Prolyl Cis-Trans Isomerase antibodyAnti-Cyclophilin-40 antibodyAnti-Cyp-40 antibodyAnti-Cyclophilin-Related Protein antibodyAnti-Rotamase D antibodyAnti-PPID antibodyAnti-CYP40 antibodyAnti-CYPD antibody |
Information sourced from Uniprot.org