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Anti-Cyclin A2 antibody [SM4920] (STJA0004920)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenKLH conjugated Synthetic peptide corresponding to Mouse Cyclin A2
General Information
| Short Description | Mouse monoclonal anti-Cyclin A2 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM4920 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB (H) 1:500-1:1000 |
| Formulation | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Ccna2 |
| Gene ID | 12428 |
| Uniprot ID | CCNA2_MOUSE |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Cyclin A2 |
Additional Info
| Post Translational Modifications | Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. Ubiquitinated during the G1 phase by the SCF(FBXO31) complex, leading to its proteasomal degradation. |
| Function | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. |
| Protein Name | Cyclin-A2Cyclin-A |
| Database Links | Reactome: R-MMU-1538133Reactome: -MMU-171319Reactome: -MMU-174184Reactome: -MMU-176408Reactome: -MMU-187577Reactome: -MMU-2559582Reactome: -MMU-2559586Reactome: -MMU-5689880Reactome: -MMU-5693607Reactome: -MMU-6804116Reactome: -MMU-6804756Reactome: -MMU-6804757Reactome: -MMU-68911Reactome: -MMU-68949Reactome: -MMU-69017Reactome: -MMU-69273Reactome: -MMU-69563Reactome: -MMU-69656 |
| Cellular Localisation | NucleusCytoplasmExclusively Nuclear During InterphaseDetected In The Nucleus And The Cytoplasm At ProphaseCytoplasmic When Associated With Scaper |
| Alternative Antibody Names | Anti-Cyclin-A2 antibodyAnti-Cyclin-A antibodyAnti-Ccna2 antibodyAnti-Ccna antibodyAnti-Cyca antibodyAnti-Cyca2 antibody |
Information sourced from Uniprot.org