| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-CYBB/GP91-PHOX (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-Recommended concentration, 1-2µg/mlELISA-antibody detection limit dilution 1:64000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CYBB |
| Gene ID: |
1536 |
| Uniprot ID: |
CY24B_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_000388.2 |
| Immunogen Sequence: |
SYLNFARKRIKNP |
| Post Translational Modifications | Glycosylated. Phosphorylated on Ser and Thr residues. Undergoes 'Lys-48'-linked polyubiquitination, likely by RNF145, triggering endoplasmic reticulum-associated degradation. |
| Function | Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. |
| Protein Name | Cytochrome B-245 Heavy ChainCgd91-PhoxCytochrome B(558 Subunit BetaCytochrome B558 Subunit BetaHeme-Binding Membrane Glycoprotein Gp91phoxNadph Oxidase 2Neutrophil Cytochrome B 91 Kda PolypeptideSuperoxide-Generating Nadph Oxidase Heavy Chain SubunitGp91-1Gp91-PhoxP22 Phagocyte B-Cytochrome |
| Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-1236973Reactome: R-HSA-3299685Reactome: R-HSA-4420097Reactome: R-HSA-5668599Reactome: R-HSA-6798695Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAs Unassembled Monomer May Localize To The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Cytochrome B-245 Heavy Chain antibodyAnti-Cgd91-Phox antibodyAnti-Cytochrome B(558 Subunit Beta antibodyAnti-Cytochrome B558 Subunit Beta antibodyAnti-Heme-Binding Membrane Glycoprotein Gp91phox antibodyAnti-Nadph Oxidase 2 antibodyAnti-Neutrophil Cytochrome B 91 Kda Polypeptide antibodyAnti-Superoxide-Generating Nadph Oxidase Heavy Chain Subunit antibodyAnti-Gp91-1 antibodyAnti-Gp91-Phox antibodyAnti-P22 Phagocyte B-Cytochrome antibodyAnti-CYBB antibodyAnti-NOX2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
