Anti-CXCL12/SDF-1 antibody [30D8] (STJA0019043)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal Stromal Cell-Derived Factor 1 antibody for use in ELISA and FC in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 30D8 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 0.61 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | Cxcl12 |
| Gene ID | 20315 |
| Uniprot ID | SDF1_MOUSE |
Additional Info
| Function | Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development.required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells. |
| Protein Name | Stromal Cell-Derived Factor 1Sdf-112-O-Tetradecanoylphorbol 13-Acetate Repressed Protein 1Tpar1C-X-C Motif Chemokine 12Pre-B Cell Growth-Stimulating FactorPbsfThymic Lymphoma Cell-Stimulating FactorTlsf |
| Database Links | Reactome: R-MMU-376176Reactome: -MMU-380108Reactome: -MMU-418594 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Stromal Cell-Derived Factor 1 antibodyAnti-Sdf-1 antibodyAnti-12-O-Tetradecanoylphorbol 13-Acetate Repressed Protein 1 antibodyAnti-Tpar1 antibodyAnti-C-X-C Motif Chemokine 12 antibodyAnti-Pre-B Cell Growth-Stimulating Factor antibodyAnti-Pbsf antibodyAnti-Thymic Lymphoma Cell-Stimulating Factor antibodyAnti-Tlsf antibodyAnti-Cxcl12 antibodyAnti-Sdf1 antibody |
Information sourced from Uniprot.org