Anti-CXADR antibody [SAA0357] (STJA0019307)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Coxsackievirus And Adenovirus Receptor antibody for use in Blocking, FC and IHC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | Blocking/FC/IHC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0357 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | CXADR |
| Gene ID | 1525 |
| Uniprot ID | CXAR_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated. Palmitoylated on Cys-259 and/or Cys-260.required for proper localization to the plasma membrane. |
| Function | Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. |
| Protein Name | Coxsackievirus And Adenovirus ReceptorCarHcarCvb3-Binding ProteinCoxsackievirus B-Adenovirus ReceptorHcvadr |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-202733 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinBasolateral Cell MembraneCell JunctionTight JunctionAdherens JunctionIn Epithelial Cells Localizes To The Apical Junction Complex Composed Of Tight And Adherens JunctionsIn Airway Epithelial Cells Localized To Basolateral Membrane But Not To Apical SurfaceIsoform 3: SecretedIsoform 4: SecretedIsoform 5: Secreted |
| Alternative Antibody Names | Anti-Coxsackievirus And Adenovirus Receptor antibodyAnti-Car antibodyAnti-Hcar antibodyAnti-Cvb3-Binding Protein antibodyAnti-Coxsackievirus B-Adenovirus Receptor antibodyAnti-Hcvadr antibodyAnti-CXADR antibodyAnti-CAR antibody |
Information sourced from Uniprot.org