Anti-CWC22 antibody (639-908) (STJ115082)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CWC22 (639-908) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CWC22 |
| Gene ID | 57703 |
| Uniprot ID | CWC22_HUMAN |
| Immunogen Region | 639-908 |
| Immunogen Sequence | LTDELREHLKNTPKVIVAQK PDVEQNKSSPSSSSSASSSS ESDSSDSDSDSSDSSSESSS EESDSSSISSHSSASANDVR KKGHGKTRSKEVDKLIRNQQ TNDRKQKERRQEHGHQETRT ERERRSEKHRDQNSSGSNWR DPITKYTSDKDVPSERNNYS RVANDRDQEMHIDLENKHGD PKKKRGERRNSFSENEKHTH RIKDSENFRRKDRSKSKEMN RKHSGSRSDEDRYQNGAER |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 639-908 of human CWC22 (NP_065994.1). |
Additional Info
| Function | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. |
| Protein Name | Pre-Mrna-Splicing Factor Cwc22 HomologNucampholin HomologFsapb |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpeckleConcentrates Around SpecklesWhich Are Sites Of Pre-Mrna Synthesis And ProcessingWhere It Colocalizes With Ejc Core Proteins |
| Alternative Antibody Names | Anti-Pre-Mrna-Splicing Factor Cwc22 Homolog antibodyAnti-Nucampholin Homolog antibodyAnti-Fsapb antibodyAnti-CWC22 antibodyAnti-KIAA1604 antibodyAnti-NCM antibody |
Information sourced from Uniprot.org