Anti-CTNNA2 antibody (167-290) (STJ117464)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CTNNA2 (167-290) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CTNNA2 |
| Gene ID | 1496 |
| Uniprot ID | CTNA2_HUMAN |
| Immunogen Region | 167-290 |
| Immunogen Sequence | TNEQDLANRFKEFGKEMVKL NYVAARRQQELKDPHCRDEM AAARGALKKNATMLYTASQA FLRHPDVAATRANRDYVFKQ VQEAIAGISNAAQATSPTDE AKGHTGIGELAAALNEFDNK IILD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 167-290 of human CTNNA2 (NP_001269526.1). |
Additional Info
| Tissue Specificity | Expressed in neural tissues, with strongest expression in fetal and adult brain. Expressed in the developing cortical plate and marginal zone of 20-week-old human fetal brain. |
| Function | May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. |
| Protein Name | Catenin Alpha-2Alpha N-CateninAlpha-Catenin-Related Protein |
| Database Links | Reactome: R-HSA-525793 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCell JunctionAdherens JunctionCell ProjectionAxonNucleus |
| Alternative Antibody Names | Anti-Catenin Alpha-2 antibodyAnti-Alpha N-Catenin antibodyAnti-Alpha-Catenin-Related Protein antibodyAnti-CTNNA2 antibodyAnti-CAPR antibody |
Information sourced from Uniprot.org