Anti-CTLA4 antibody [Ipilimumab] (STJA0043149)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
General Information
| Short Description | Mouse monoclonal Cytotoxic T-lymphocyte protein 4 antibody for use in ELISA, FCM and FUNC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA, FCM, FUNC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | Ipilimumab |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant. |
| Dilution Range | Reconstitute in sterile water for a stock solution. ELISA 1:2000-1:20000 |
| Formulation | Liquid, 0.01M PBS pH 7.4 |
| Storage Instruction | Store at 2-8°C for frequent use. Store at-20 to-80°C for 1 year. |
| Endotoxin | Please contact with the lab for this information. |
Target Information
| Gene Symbol | CTLA4 |
| Gene ID | 1493 |
| Uniprot ID | CTLA4_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface. |
| Function | Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. |
| Protein Name | Cytotoxic T-Lymphocyte Protein 4Cytotoxic T-Lymphocyte-Associated Antigen 4Ctla-4Cd Antigen Cd152 |
| Database Links | Reactome: R-HSA-389356Reactome: R-HSA-389513Reactome: R-HSA-8877330 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinExists Primarily An Intracellular Antigen Whose Surface Expression Is Tightly Regulated By Restricted Trafficking To The Cell Surface And Rapid Internalization |
| Alternative Antibody Names | Anti-Cytotoxic T-Lymphocyte Protein 4 antibodyAnti-Cytotoxic T-Lymphocyte-Associated Antigen 4 antibodyAnti-Ctla-4 antibodyAnti-Cd Antigen Cd152 antibodyAnti-CTLA4 antibodyAnti-CD152 antibody |
Information sourced from Uniprot.org