Anti-CTLA4 antibody (150-200) {Biotin} (STJ500622)

Name: Anti-CTLA4 antibody (150-200) {Biotin} (STJ500622)
SKU: STJ500622-100
Price: 686.55 USD
Availability: InStock

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SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationBiotin

IsotypeIgG

ImmunogenSynthetic peptide taken within amino acid region 150-200 on CTLA4 protein.

STJ500622-100

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Short Description	Rabbit polyclonal antibody anti-CTLA4 (150-200) is suitable for use in ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Applications	ELISA/ICC/IF/IHC/IP/WB
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Biotin
Concentration	0.7 µg/µl
Purification	Affinity Purified
Dilution Range	WB: 1:500 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100 ICC: 1:100 IF: 1:100
Formulation	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Storage Instruction	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol	CTLA4
Gene ID	1493
Uniprot ID	CTLA4_HUMAN
Immunogen	Synthetic peptide taken within amino acid region 150-200 on CTLA4 protein.
Immunogen Region	150-200

Tissue Specificity	Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
Post Translational Modifications	N-glycosylation is important for dimerization. Phosphorylation at Tyr-201 prevents binding to the AP-2 adapter complex, blocks endocytosis, and leads to retention of CTLA4 on the cell surface.
Function	Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Protein Name	Cytotoxic T-Lymphocyte Protein 4 Cytotoxic T-Lymphocyte-Associated Antigen 4 Ctla-4 Cd Antigen Cd152
Database Links	Reactome: R-HSA-389513 Reactome: R-HSA-8877330
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Exists Primarily An Intracellular Antigen Whose Surface Expression Is Tightly Regulated By Restricted Trafficking To The Cell Surface And Rapid Internalization
Alternative Antibody Names	Anti-Cytotoxic T-Lymphocyte Protein 4 antibody Anti-Cytotoxic T-Lymphocyte-Associated Antigen 4 antibody Anti-Ctla-4 antibody Anti-Cd Antigen Cd152 antibody Anti-CTLA4 antibody Anti-CD152 antibody

Information sourced from Uniprot.org