Anti-Ctip1 antibody [R07-2N7] (STJA0036599)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Ctip1
General Information
| Short Description | Rabbit monoclonal anti-Ctip1 for use in WB, IHC-P, ICC, IF and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/FC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-2N7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | BCL11A |
| Gene ID | 53335 |
| Uniprot ID | BC11A_HUMAN |
| Immunogen | A synthesized peptide derived from human Ctip1 |
Additional Info
| Tissue Specificity | Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development. Isoform 1: Expressed in fetal and adult brain, and in the plasmacytoid dendritic cell. |
| Post Translational Modifications | Sumoylated with SUMO1. |
| Function | Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1.hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of NR2F2. |
| Protein Name | Bcl11 Transcription Factor AB-Cell Cll/Lymphoma 11aB-Cell Lymphoma/Leukemia 11aBcl-11aCoup-Tf-Interacting Protein 1Ecotropic Viral Integration Site 9 Protein HomologEvi-9Zinc Finger Protein 856 |
| Database Links | Reactome: R-HSA-9700645Reactome: R-HSA-9725370 |
| Cellular Localisation | CytoplasmNucleusChromosomeAssociates With The Nuclear BodyColocalizes With Sumo1 And Senp2 In Nuclear SpecklesIsoform 1: Nucleus MatrixColocalizes With Bcl6 In Nuclear ParaspecklesIsoform 2: CytoplasmPredominantly Localized In The Nucleus In Nuclear ParaspecklesIsoform 3: CytoplasmPredominantly Localized In The Cytoplasm In The Absence Of Interaction With Isoform 1 And Isoform 2In Presence Of Isoform 1 Or Isoform 2Translocates From The Cytoplasm Into Nuclear Paraspeckles |
| Alternative Antibody Names | Anti-Bcl11 Transcription Factor A antibodyAnti-B-Cell Cll/Lymphoma 11a antibodyAnti-B-Cell Lymphoma/Leukemia 11a antibodyAnti-Bcl-11a antibodyAnti-Coup-Tf-Interacting Protein 1 antibodyAnti-Ecotropic Viral Integration Site 9 Protein Homolog antibodyAnti-Evi-9 antibodyAnti-Zinc Finger Protein 856 antibodyAnti-BCL11A antibodyAnti-CTIP1 antibodyAnti-EVI9 antibodyAnti-KIAA1809 antibodyAnti-ZNF856 antibody |
Information sourced from Uniprot.org