Anti-CTDSPL antibody (Internal) (STJ71564)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CTDSPL (Internal) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Applications | Pep-ELISA/IF/FC |
| Host | Goat |
| Reactivity | Human/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary testing showed a band at approx 28kDa in nuclear lysate of cell lines A431 and HeLa, after 1-2µg/ml antibody staining (calculated Mwt of 29.9kDa according to NP_005799.2). |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CTDSPL |
| Gene ID | 10217 |
| Uniprot ID | CTDSL_HUMAN |
| Accession Number | NP_001008393.1; NP_005799.2 |
| Immunogen Region | Internal |
| Immunogen Sequence | QCNVSLKKQRSRS |
| Specificity | This antibody is expected to recognise both isoforms (NP_001008393.1; NP_005799.2). |
Additional Info
| Function | Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. |
| Protein Name | Ctd Small Phosphatase-Like ProteinCtdsp-LikeCarboxy-Terminal Domain Rna Polymerase Ii Polypeptide A Small Phosphatase 3Nif-Like ProteinNuclear Lim Interactor-Interacting Factor 1Nli-Interacting Factor 1Protein Ya22Hya22Rbsp3Small C-Terminal Domain Phosphatase 3Scp3Small Ctd Phosphatase 3 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ctd Small Phosphatase-Like Protein antibodyAnti-Ctdsp-Like antibodyAnti-Carboxy-Terminal Domain Rna Polymerase Ii Polypeptide A Small Phosphatase 3 antibodyAnti-Nif-Like Protein antibodyAnti-Nuclear Lim Interactor-Interacting Factor 1 antibodyAnti-Nli-Interacting Factor 1 antibodyAnti-Protein Ya22 antibodyAnti-Hya22 antibodyAnti-Rbsp3 antibodyAnti-Small C-Terminal Domain Phosphatase 3 antibodyAnti-Scp3 antibodyAnti-Small Ctd Phosphatase 3 antibodyAnti-CTDSPL antibodyAnti-C3orf8 antibodyAnti-NIF1 antibodyAnti-NIFL antibodyAnti-SCP3 antibodyAnti-YA22 antibody |
Information sourced from Uniprot.org