Anti-CSNK1A1 antibody [3C10F7/3C10G5/PMC01/4D12B3/3C10F7C11] (STJ97894)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of Casein Kinase I Alpha expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Casein kinase I isoform alpha for use in WB, IHC, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3C10F7/3C10G5/PMC01/4D12B3/3C10F7C11 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000IHC 1:200-1:1000ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CSNK1A1 |
| Gene ID | 1452 |
| Uniprot ID | KC1A_HUMAN |
| Immunogen | Purified recombinant fragment of Casein Kinase I Alpha expressed in E. Coli. |
| Specificity | Casein Kinase I Alpha Monoclonal Antibody detects endogenous levels of Casein Kinase I Alpha protein. |
Additional Info
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor. Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3. |
| Protein Name | Casein Kinase I Isoform AlphaCki-AlphaCk1 |
| Database Links | Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5610783Reactome: R-HSA-5610785Reactome: R-HSA-5635838Reactome: R-HSA-9694631 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeChromosomeCentromereKinetochoreNucleus SpeckleCilium Basal BodySpindleLocalizes To The Centrosome In Interphase CellsAnd To Kinetochore Fibers During MitosisAlso Recruited To The Keratin Cytoskeleton |
| Alternative Antibody Names | Anti-Casein Kinase I Isoform Alpha antibodyAnti-Cki-Alpha antibodyAnti-Ck1 antibodyAnti-CSNK1A1 antibody |
Information sourced from Uniprot.org