Anti-CSN4 antibody [R38-5L-5] (STJA0035591)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human COPS4
General Information
| Short Description | Rabbit monoclonal anti-CSN4 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R38-5L-5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | COPS4 |
| Gene ID | 51138 |
| Uniprot ID | CSN4_HUMAN |
| Immunogen | A synthesized peptide derived from human COPS4 |
Additional Info
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Protein Name | Cop9 Signalosome Complex Subunit 4Sgn4Signalosome Subunit 4Jab1-Containing Signalosome Subunit 4 |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664Reactome: R-HSA-9013422 |
| Cellular Localisation | CytoplasmNucleusCytoplasmic VesicleSecretory VesicleSynaptic Vesicle |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 4 antibodyAnti-Sgn4 antibodyAnti-Signalosome Subunit 4 antibodyAnti-Jab1-Containing Signalosome Subunit 4 antibodyAnti-COPS4 antibodyAnti-CSN4 antibody |
Information sourced from Uniprot.org