Anti-CSN2/TRIP15 antibody (C-Term) (STJ70367)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CSN2/TRIP15 (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx. 48kDa band observed in lysates of Mouse putuitary cell line NIH3T3 (calculated MW of 51.6kDa according to NP_004227.1). Recommended concentration: 1-3µg/ml.IHC: In paraffi |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | COPS2 |
| Gene ID | 9318 |
| Uniprot ID | CSN2_HUMAN |
| Accession Number | NP_004227.1; NP_001137359.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | LNSLNQAVVSKLA |
Additional Info
| Function | Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. |
| Protein Name | Cop9 Signalosome Complex Subunit 2Sgn2Signalosome Subunit 2Alien HomologJab1-Containing Signalosome Subunit 2Thyroid Receptor-Interacting Protein 15Tr-Interacting Protein 15Trip-15 |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664Reactome: R-HSA-9013422 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 2 antibodyAnti-Sgn2 antibodyAnti-Signalosome Subunit 2 antibodyAnti-Alien Homolog antibodyAnti-Jab1-Containing Signalosome Subunit 2 antibodyAnti-Thyroid Receptor-Interacting Protein 15 antibodyAnti-Tr-Interacting Protein 15 antibodyAnti-Trip-15 antibodyAnti-COPS2 antibodyAnti-CSN2 antibodyAnti-TRIP15 antibody |
Information sourced from Uniprot.org