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Anti-CSK antibody (1-200) (STJ23240)

Western blot analysis of various lysates using CSK Rabbit polyclonal antibody (STJ23240) at 1:1000 dilution. Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/ proteins: 25 Mu g per lane. Blocking buffer: 3 % nonfat dry milk in TBST. Detection:ECL Enhanced Kit. Exposuretime: 90s.

Anti-CSK antibody (1-200) (STJ23240)

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STJ23240

£212.50 - £501.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-CSK (1-200) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CSK
Gene ID:	1445
Uniprot ID:	CSK_HUMAN
Immunogen Region:	1-200
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CSK (NP_001120662.1).
Immunogen Sequence:	MSAIQAAWPSGTECIAKYNF HGTAEQDLPFCKGDVLTIVA VTKDPNWYKAKNKVGREGII PANYVQKREGVKAGTKLSLM PWFHGKITREQAERLLYPPE TGLFLVRESTNYPGDYTLCV SCDGKVEHYRIMYHASKLSI DEEVYFENLMQLVEHYTSDA DGLCTRLIKPKVMEGTVAAQ DEFYRSGWALNMKELKLLQT

Tissue Specificity	Expressed in lung and macrophages.
Post Translational Modifications	Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated.
Function	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Protein Name	Tyrosine-Protein Kinase Csk C-Src Kinase Protein-Tyrosine Kinase Cyl
Database Links	Reactome: R-HSA-180292 Reactome: R-HSA-202427 Reactome: R-HSA-354192 Reactome: R-HSA-389948 Reactome: R-HSA-5674135 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-9013407 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 Reactome: R-HSA-9706369
Cellular Localisation	Cytoplasm Cell Membrane Mainly Cytoplasmic Also Present In Lipid Rafts
Alternative Antibody Names	Anti-Tyrosine-Protein Kinase Csk antibody Anti-C-Src Kinase antibody Anti-Protein-Tyrosine Kinase Cyl antibody Anti-CSK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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