Anti-CSF3R antibody (650-750) (STJ29974)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CSF3R (650-750) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CSF3R |
| Gene ID | 1441 |
| Uniprot ID | CSF3R_HUMAN |
| Immunogen Region | 650-750 |
| Immunogen Sequence | CSPNRKNPLWPSVPDPAHSS LGSWVPTIMEEDAFQLPGLG TPPITKLTVLEEDEKKPVPW ESHNSSETCGLPTLVQTYVL QGDPRAVSTQPQSQSGTSDQ V |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 650-750 of human CSF3R (NP_000751.1). |
Additional Info
| Tissue Specificity | One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta. |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differentiation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. |
| Protein Name | Granulocyte Colony-Stimulating Factor ReceptorG-Csf ReceptorG-Csf-RCd Antigen Cd114 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-9616222Reactome: R-HSA-9674555Reactome: R-HSA-9705462 |
| Cellular Localisation | Isoform 2: SecretedCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Granulocyte Colony-Stimulating Factor Receptor antibodyAnti-G-Csf Receptor antibodyAnti-G-Csf-R antibodyAnti-Cd Antigen Cd114 antibodyAnti-CSF3R antibodyAnti-GCSFR antibody |
Information sourced from Uniprot.org