| Host: | Rabbit |
| Applications: | FC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-CS1 for use in FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | DM9 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Purification: | Affinity Chromatography |
| Dilution Range: | FC 1:50-1:100ELISA 1:10000 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | SLAMF7 |
| Gene ID: | 57823 |
| Uniprot ID: | SLAF7_HUMAN |
| Immunogen: | Recombinant human CS1 protein |
| Tissue Specificity | Expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. Expressed in monocytes. Isoform 3 is expressed at much lower level than isoform 1. |
| Function | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines. Isoform 3 does not mediate any NK cell activation. |
| Protein Name | Slam Family Member 7Cd2 Subset 1Cd2-Like Receptor-Activating Cytotoxic CellsCraccMembrane Protein Foap-12Novel Ly9Protein 19aCd Antigen Cd319 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Slam Family Member 7 antibodyAnti-Cd2 Subset 1 antibodyAnti-Cd2-Like Receptor-Activating Cytotoxic Cells antibodyAnti-Cracc antibodyAnti-Membrane Protein Foap-12 antibodyAnti-Novel Ly9 antibodyAnti-Protein 19a antibodyAnti-Cd Antigen Cd319 antibodyAnti-SLAMF7 antibodyAnti-CS1 antibodyAnti-UNQ576 antibodyAnti-PRO1138 antibody |
Information sourced from Uniprot.org
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