Anti-Crystallin alpha B/CRYAB antibody (1-175 aa) [2E8.] (STJA0041471)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant human Crystallin alpha B (1-175 aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-Crystallin alpha B/CRYAB (1-175 aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2E8. |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-G affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRYAB |
| Gene ID | 1410 |
| Uniprot ID | CRYAB_HUMAN |
| Accession Number | NP_001876.1 |
| Immunogen | Recombinant human Crystallin alpha B (1-175 aa) purified from E. coli |
| Immunogen Region | 1-175 aa |
Additional Info
| Tissue Specificity | Lens as well as other tissues. Expressed in myocardial tissue. |
| Function | May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome. |
| Protein Name | Alpha-Crystallin B ChainAlpha(B-CrystallinHeat Shock Protein Beta-5Hspb5Heat Shock Protein Family B Member 5Renal Carcinoma Antigen Ny-Ren-27Rosenthal Fiber Component |
| Database Links | Reactome: R-HSA-3371571 |
| Cellular Localisation | CytoplasmNucleusSecretedLysosomeTranslocates To The Nucleus During Heat Shock And Resides In Sub-Nuclear Structures Known As Sc35 Speckles Or Nuclear Splicing SpecklesLocalizes At The Z-Bands And The Intercalated Disk In CardiomyocytesCan Be SecretedThe Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion |
| Alternative Antibody Names | Anti-Alpha-Crystallin B Chain antibodyAnti-Alpha(B-Crystallin antibodyAnti-Heat Shock Protein Beta-5 antibodyAnti-Hspb5 antibodyAnti-Heat Shock Protein Family B Member 5 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-27 antibodyAnti-Rosenthal Fiber Component antibodyAnti-CRYAB antibodyAnti-CRYA2 antibodyAnti-HSPB5 antibody |
Information sourced from Uniprot.org