Anti-CRYM antibody (1-314) (STJ23234)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CRYM (1-314) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRYM |
| Gene ID | 1428 |
| Uniprot ID | CRYM_HUMAN |
| Immunogen Region | 1-314 |
| Immunogen Sequence | MSRVPAFLSAAEVEEHLRSS SLLIPPLETALANFSSGPEG GVMQPVRTVVPVTKHRGYLG VMPAYSAAEDALTTKLVTFY EDRGITSVVPSHQATVLLFE PSNGTLLAVMDGNVITAKRT AAVSAIATKFLKPPSSEVLC ILGAGVQAYSHYEIFTEQFS FKEVRIWNRTKENAEKFADT VQGEVRVCSSVQEAVAGADV IITVTLATEPILFGEWVKPG AHINAVGASRPDWRELDDE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human CRYM (NP_001879.1). |
Additional Info
| Tissue Specificity | Expressed in neural tissues, muscle and kidney. Expressed in the inner ear. |
| Function | Catalyzes the NAD(P)H-dependent reduction of imine double bonds of a number of cyclic ketimine substrates, including sulfur-containing cyclic ketimines. Under physiological conditions, it efficiently catalyzes delta(1)-piperideine-2-carboxylate (P2C) and delta(1)-pyrroline-2-carboxylate (Pyr2C) reduction, suggesting a central role in lysine and glutamate metabolism. Additional substrates are delta(2)-thiazoline-2-carboxylate (T2C), 3,4-dehydrothiomorpholine-3-carboxylate (AECK), and (R)-lanthionine ketimine (LK) that is reduced at very low rate compared to other substrates. Also catalyzes the NAD(P)H-dependent reduction of (S)-cystathionine ketimine (CysK). |
| Protein Name | Ketimine Reductase Mu-Crystallin1-Piperideine-2-Carboxylate/1-Pyrroline-2-Carboxylate ReductaseP2c/Pyr2c ReductaseNadp-Regulated Thyroid-Hormone-Binding Protein |
| Database Links | Reactome: R-HSA-71064 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ketimine Reductase Mu-Crystallin antibodyAnti-1-Piperideine-2-Carboxylate/1-Pyrroline-2-Carboxylate Reductase antibodyAnti-P2c/Pyr2c Reductase antibodyAnti-Nadp-Regulated Thyroid-Hormone-Binding Protein antibodyAnti-CRYM antibodyAnti-THBP antibody |
Information sourced from Uniprot.org