Anti-CRTAM antibody (260-340 aa) (STJ192377)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 260-340
General Information
| Short Description | Rabbit polyclonal anti-Cytotoxic and regulatory T-cell molecule (260-340 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRTAM |
| Gene ID | 56253 |
| Uniprot ID | CRTAM_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 260-340 |
| Immunogen Region | 260-340 aa |
| Specificity | CRTAM Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation. Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity. Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production. By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. |
| Protein Name | Cytotoxic And Regulatory T-Cell MoleculeClass-I Mhc-Restricted T-Cell-Associated MoleculeCd Antigen Cd355 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIn A Subset Of Cd4+ T-CellsColocalizes With Scrib At The Immunological Synapse During The Late Phase Of T-Cell Activation |
| Alternative Antibody Names | Anti-Cytotoxic And Regulatory T-Cell Molecule antibodyAnti-Class-I Mhc-Restricted T-Cell-Associated Molecule antibodyAnti-Cd Antigen Cd355 antibodyAnti-CRTAM antibody |
Information sourced from Uniprot.org