• Anti-CRIPTO antibody [3A6] (STJ97967)
  • Western blot analysis using Cripto monoclonal antibody against HEK293 (1) and TDGF1-hIgGFc transfected HEK293 (2) cell lysate.

Anti-CRIPTO antibody [3A6] (STJ97967)

SKU:
STJ97967

Current Stock:
Host: Mouse
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Protein Cripto is suitable for use in Western Blot and ELISA research applications.
Clonality: Monoclonal
Clone ID: 3A6
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRIPTO
Gene ID: 6997
Uniprot ID: TDGF1_HUMAN
Specificity: Cripto Monoclonal Antibody detects endogenous levels of Cripto protein.
Immunogen: Purified recombinant fragment of human Cripto expressed in E. Coli.
Post Translational Modifications The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing CRIPTO as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form.
Function GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.
Protein Name Protein Cripto
Cripto - Egf-Cfc Family Member
Cripto-1 Growth Factor
Crgf
Epidermal Growth Factor-Like Cripto Protein Cr1
Teratocarcinoma-Derived Growth Factor 1
Database Links Reactome: R-HSA-1181150
Reactome: R-HSA-1433617
Reactome: R-HSA-2892247
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Secreted
Released From The Cell Membrane By Gpi Cleavage
Alternative Antibody Names Anti-Protein Cripto antibody
Anti-Cripto - Egf-Cfc Family Member antibody
Anti-Cripto-1 Growth Factor antibody
Anti-Crgf antibody
Anti-Epidermal Growth Factor-Like Cripto Protein Cr1 antibody
Anti-Teratocarcinoma-Derived Growth Factor 1 antibody
Anti-CRIPTO antibody
Anti-CRIPTO-1 antibody
Anti-TDGF1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance