| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Corticotropin-releasing factor receptor 2 (71-120 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CRHR2 |
| Gene ID: | 1395 |
| Uniprot ID: | CRFR2_HUMAN |
| Immunogen Region: | 71-120 aa |
| Specificity: | CRF-RII Polyclonal Antibody detects endogenous levels of CRF-RII protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CRHR2 at the amino acid range 71-120 |
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. |
| Protein Name | Corticotropin-Releasing Factor Receptor 2Crf-R-2Crf-R2Crfr-2Corticotropin-Releasing Hormone Receptor 2Crh-R-2Crh-R2 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555Reactome: R-HSA-422085 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Corticotropin-Releasing Factor Receptor 2 antibodyAnti-Crf-R-2 antibodyAnti-Crf-R2 antibodyAnti-Crfr-2 antibodyAnti-Corticotropin-Releasing Hormone Receptor 2 antibodyAnti-Crh-R-2 antibodyAnti-Crh-R2 antibodyAnti-CRHR2 antibodyAnti-CRF2R antibodyAnti-CRH2R antibody |
Information sourced from Uniprot.org