Anti-CRHR2 antibody (50-150) [PTR1205] (STJA0006274)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenSynthesized peptide derived from human CRHR2 AA range: 50-150
General Information
| Short Description | Mouse monoclonal anti-Corticotropin-releasing factor receptor 2 (50-150) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PTR1205 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRHR2 |
| Gene ID | 1395 |
| Uniprot ID | CRFR2_HUMAN |
| Immunogen | Synthesized peptide derived from human CRHR2 AA range: 50-150 |
| Immunogen Region | 50-150 |
| Specificity | This antibody detects endogenous levels of CRHR2 at Human, Predict react with Mouse, Rat |
Additional Info
| Post Translational Modifications | A N-glycosylation site within the signal peptide impedes its proper cleavage and function. |
| Function | G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. |
| Protein Name | Corticotropin-Releasing Factor Receptor 2Crf-R-2Crf-R2Crfr-2Corticotropin-Releasing Hormone Receptor 2Crh-R-2Crh-R2 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555Reactome: R-HSA-422085 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Corticotropin-Releasing Factor Receptor 2 antibodyAnti-Crf-R-2 antibodyAnti-Crf-R2 antibodyAnti-Crfr-2 antibodyAnti-Corticotropin-Releasing Hormone Receptor 2 antibodyAnti-Crh-R-2 antibodyAnti-Crh-R2 antibodyAnti-CRHR2 antibodyAnti-CRF2R antibodyAnti-CRH2R antibody |
Information sourced from Uniprot.org