Anti-CREPT antibody [3E10#] (STJA0019707)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Regulation Of Nuclear Pre-Mrna Domain-Containing Protein 1b antibody for use in ELISA, IF, IHC and WB in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/IF/IHC/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3E10# |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | RPRD1B |
| Gene ID | 58490 |
| Uniprot ID | RPR1B_HUMAN |
Additional Info
| Function | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. |
| Protein Name | Regulation Of Nuclear Pre-Mrna Domain-Containing Protein 1bCell Cycle-Related And Expression-Elevated Protein In Tumor |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Regulation Of Nuclear Pre-Mrna Domain-Containing Protein 1b antibodyAnti-Cell Cycle-Related And Expression-Elevated Protein In Tumor antibodyAnti-RPRD1B antibodyAnti-C20orf77 antibodyAnti-CREPT antibody |
Information sourced from Uniprot.org