Anti-CREM antibody (1-100) (STJ27591)

Name: Anti-CREM antibody (1-100) (STJ27591)
SKU: STJ27591
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ27591

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Short Description	Rabbit polyclonal CREM (1-100) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:100-1:500 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	CREM
Gene ID	1390
Uniprot ID	CREM_HUMAN
Immunogen Region	1-100
Immunogen Sequence	MSKCARKKYIKTNPRQMTME TVESQHDGSITASLTESKSA HVQTQTGQNSIPALAQVAAI AETDESAESEGVIDSHKRRE ILSRRPSYRKILNELSSDVP
Specificity	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CREM (NP_853549.1).

Tissue Specificity	Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Post Translational Modifications	Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. Stimulated by phosphorylation. Phosphorylated on Ser-116 by TSSK4 in vitro.
Function	Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter.
Protein Name	Camp-Responsive Element Modulator Inducible Camp Early Repressor Icer
Database Links	Reactome: R-HSA-400253 Q03060-6
Cellular Localisation	Nucleus Isoform 6: Cytoplasm
Alternative Antibody Names	Anti-Camp-Responsive Element Modulator antibody Anti-Inducible Camp Early Repressor antibody Anti-Icer antibody Anti-CREM antibody

Information sourced from Uniprot.org