Anti-CREB3L4 antibody (200-280 aa) (STJ190423)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 200-280
General Information
| Short Description | Rabbit polyclonal anti-Cyclic AMP-responsive element-binding protein 3-like protein 4 (200-280 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CREB3L4 |
| Gene ID | 148327 |
| Uniprot ID | CR3L4_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 200-280 |
| Immunogen Region | 200-280 aa |
| Specificity | CR3L4 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | N-glycosylated in the C-terminal region. Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region. |
| Function | Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-TGTACGTGAGT-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4Camp-Responsive Element-Binding Protein 3-Like Protein 4Androgen-Induced Basic Leucine Zipper ProteinAibzipAttaching To Cre-Like 1Atce1Cyclic Amp-Responsive Element-Binding Protein 4Creb-4Camp-Responsive Element-Binding Protein 4Transcript Induced In Spermiogenesis Protein 40Tisp40Hjal Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 |
| Database Links | Reactome: R-HSA-8874211 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinGolgi Apparatus MembraneMay Also Be Located In Golgi ApparatusProcessed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4: NucleusUnder Er Stress The Cleaved N-Terminal Cytoplasmic Domain Translocates Into The Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-Camp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-Androgen-Induced Basic Leucine Zipper Protein antibodyAnti-Aibzip antibodyAnti-Attaching To Cre-Like 1 antibodyAnti-Atce1 antibodyAnti-Cyclic Amp-Responsive Element-Binding Protein 4 antibodyAnti-Creb-4 antibodyAnti-Camp-Responsive Element-Binding Protein 4 antibodyAnti-Transcript Induced In Spermiogenesis Protein 40 antibodyAnti-Tisp40 antibodyAnti-Hjal Cleaved Into - Processed Cyclic Amp-Responsive Element-Binding Protein 3-Like Protein 4 antibodyAnti-CREB3L4 antibodyAnti-AIBZIP antibodyAnti-CREB4 antibodyAnti-JAL antibody |
Information sourced from Uniprot.org