| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein crumbs homolog 3 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CRB3 |
| Gene ID: |
92359 |
| Uniprot ID: |
CRUM3_HUMAN |
| Specificity: |
This antibody detects endogenous levels of CRB3 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human CRB3 |
| Function | Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions. Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7. |
| Protein Name | Protein Crumbs Homolog 3 |
| Database Links | Reactome: R-HSA-420029Reactome: R-HSA-9705677 |
| Cellular Localisation | Apical Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionTight JunctionLocalizes Primarily To The Apical Membrane With A Small Fraction In The Upper Part Of Tight Junctions Of Epithelial Cells |
| Alternative Antibody Names | Anti-Protein Crumbs Homolog 3 antibodyAnti-CRB3 antibodyAnti-UNQ588 antibodyAnti-PRO1158 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
