Anti-CRAT antibody (380-626) (STJ28448)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CRAT (380-626) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CRAT |
| Gene ID | 1384 |
| Uniprot ID | CACP_HUMAN |
| Immunogen Region | 380-626 |
| Immunogen Sequence | KLRFNITPEIKSDIEKAKQN LSIMIQDLDITVMVFHHFGK DFPKSEKLSPDAFIQMALQL AYYRIYGQACATYESASLRM FHLGRTDTIRSASMDSLTFV KAMDDSSVTEHQKVELLRKA VQAHRGYTDRAIRGEAFDRH LLGLKLQAIEDLVSMPDIFM DTSYAIAMHFHLSTSQVPAK TDCVMFFGPVVPDGYGVCYN PMEAHINFSLSAYNSCAETN AARLAHYLEKALLDMRALL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 380-626 of human CRAT (NP_000746.3). |
Additional Info
| Tissue Specificity | Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney. |
| Function | Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates. |
| Protein Name | Carnitine O-AcetyltransferaseCarnitine AcetylaseCarnitine AcetyltransferaseCatCrat |
| Database Links | Reactome: R-HSA-389887Reactome: R-HSA-9033241 |
| Cellular Localisation | Endoplasmic ReticulumPeroxisomeMitochondrion Inner MembranePeripheral Membrane ProteinMatrix SideIsoform 1: MitochondrionIsoform 2: Peroxisome |
| Alternative Antibody Names | Anti-Carnitine O-Acetyltransferase antibodyAnti-Carnitine Acetylase antibodyAnti-Carnitine Acetyltransferase antibodyAnti-Cat antibodyAnti-Crat antibodyAnti-CRAT antibodyAnti-CAT1 antibody |
Information sourced from Uniprot.org