• Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-CD35 (ABT-CD35) antibody. The HRP-conjugated Goat anti- mouse IgG (H + L) antibody was used to detect the antibody. Lane 1: DaudiPredicted band size: 180kDaObserved band size: 250kDa
  • Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-CD35 (ABT-CD35) antibody. The HRP-conjugated Goat anti- mouse IgG (H + L) antibody was used to detect the antibody. Lane 1: DaudiPredicted band size: 180kDaObserved band size: 250kDa
  • Human kidney tissue was stained with Anti-CD35 (ABT-CD35) Antibody
  • Human liver tissue was stained with Anti-CD35 (ABT-CD35) Antibody
  • Human tonsil tissue was stained with Anti-CD35 (ABT-CD35) Antibody

Anti-CR1 antibody (300-400 aa) [ABT-CD35] (STJ196877)

SKU:
STJ196877

€210.00 - €282.50
Current Stock:
Host: Mouse
Applications: IHC/WB/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Complement receptor type 1 (300-400 aa) is suitable for use in Immunohistochemistry, Western Blot and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: ABT-CD35
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range: IHC-P 1:100-500
WB 1:200-1000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CR1
Gene ID: 1378
Uniprot ID: CR1_HUMAN
Immunogen Region: 300-400 aa
Specificity: This antibody detects endogenous levels of human CD35. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section
Immunogen: Synthesized peptide derived from the human CD35 at the amino acid range 300-400
Function Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages. Mediates the binding by these cells of particles and immune complexes that have activated complement to eliminate them from the circulation. Acts also in the inhibition of spontaneous complement activation by impairing the formation and function of the alternative and classical pathway C3/C5 convertases, and by serving as a cofactor for the cleavage by factor I of C3b to iC3b, C3c and C3d,g, and of C4b to C4c and C4d. Also plays a role in immune regulation by contributing, upon ligand binding, to the generation of regulatory T cells from activated helper T cells. (Microbial infection) Acts as a receptor for Epstein-Barr virus.
Protein Name Complement Receptor Type 1
C3b/C4b Receptor
Cd Antigen Cd35
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-8877330
Reactome: R-HSA-977606
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Complement Receptor Type 1 antibody
Anti-C3b/C4b Receptor antibody
Anti-Cd Antigen Cd35 antibody
Anti-CR1 antibody
Anti-C3BR antibody

Information sourced from Uniprot.org

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