Anti-CPT1C antibody (Internal) (STJ71731)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CPT1C (Internal) is suitable for use in ELISA and Immunofluorescence research applications. |
| Applications | Pep-ELISA/IF |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.IF: Strong expression of the protein seen in the plasma membrane and cytoplasm of U251cells. Recommended concentration: 10µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CPT1C |
| Gene ID | 126129 |
| Uniprot ID | CPT1C_HUMAN |
| Accession Number | NP_689572.1; NP_001129524.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | KSSTKTDSHRLGQH |
| Specificity | This antibody is expected to recognise both reported isoforms (NP_689572.1; NP_001129524.1). Reported variants represent identical protein (NP_001186681.1; NP_001186682.1; NP_689572.1). |
Additional Info
| Function | Palmitoyl thioesterase specifically expressed in the endoplasmic reticulum of neurons. Modulates the trafficking of the glutamate receptor, AMPAR, to plasma membrane through depalmitoylation of GRIA1. Also regulates AMPR trafficking through the regulation of SACM1L phosphatidylinositol-3-phosphatase activity by interaction in a malonyl-CoA dependent manner. Binds malonyl-CoA and couples malonyl-CoA to ceramide levels, necessary for proper spine maturation and contributing to systemic energy homeostasis and appetite control. Binds to palmitoyl-CoA, but does not have carnitine palmitoyltransferase 1 catalytic activity or at very low levels. |
| Protein Name | Palmitoyl Thioesterase Cpt1cCarnitine O-Palmitoyltransferase 1 - Brain IsoformCpti-BCarnitine Palmitoyltransferase 1cCarnitine Palmitoyltransferase ICpt I-C |
| Cellular Localisation | Cell ProjectionDendriteAxonEndoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLocalized In The Soma And Dendritic And Axonal Projections |
| Alternative Antibody Names | Anti-Palmitoyl Thioesterase Cpt1c antibodyAnti-Carnitine O-Palmitoyltransferase 1 - Brain Isoform antibodyAnti-Cpti-B antibodyAnti-Carnitine Palmitoyltransferase 1c antibodyAnti-Carnitine Palmitoyltransferase I antibodyAnti-Cpt I-C antibodyAnti-CPT1C antibodyAnti-CATL1 antibody |
Information sourced from Uniprot.org