| Short Description : | Rabbit polyclonal CPSF1 (700-950) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CPSF1 |
| Gene ID: | 29894 |
| Uniprot ID: | CPSF1_HUMAN |
| Immunogen Region: | 700-950 |
| Immunogen Sequence: | LYRDLSGMFTTESRLGGARD ELGGRSGPEAEGLGSETSPT VDDEEEMLYGDSGSLFSPSK EEARRSSQPPADRDPAPFRA EPTHWCLLVRENGTMEIYQL PDWRLVFLVKNFPVGQRVLV DSSFGQPTTQGEARREEATR QGELPLVKEVLLVALGSRQS RPYLLVHVDQELLIYEAFPH DSQLGQGNLKVRFKKVPHNI NFREKKPKPSKKKAEGGGAE EGAGARGRVARFRYFEDIY |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-950 of human CPSF1 (NP_037423.2). |
| Tissue Specificity | Widely expressed, with high expression in the retina. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction. May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain. |
| Protein Name | Cleavage And Polyadenylation Specificity Factor Subunit 1Cleavage And Polyadenylation Specificity Factor 160 Kda SubunitCpsf 160 Kda Subunit |
| Database Links | Reactome: R-HSA-159231Reactome: R-HSA-6784531Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595 |
| Cellular Localisation | NucleusNucleoplasm |
| Alternative Antibody Names | Anti-Cleavage And Polyadenylation Specificity Factor Subunit 1 antibodyAnti-Cleavage And Polyadenylation Specificity Factor 160 Kda Subunit antibodyAnti-Cpsf 160 Kda Subunit antibodyAnti-CPSF1 antibodyAnti-CPSF160 antibody |
Information sourced from Uniprot.org
