Anti-CPS1 antibody [R06-6H8] (STJA0036762)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human CPS1
General Information
| Short Description | Rabbit monoclonal anti-CPS1 for use in WB, IHC-P, ICC, IF and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-6H8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:50 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CPS1 |
| Gene ID | 1373 |
| Uniprot ID | CPSM_HUMAN |
| Immunogen | A synthesized peptide derived from human CPS1 |
Additional Info
| Tissue Specificity | Primarily in the liver and small intestine. |
| Post Translational Modifications | Undergoes proteolytic cleavage in the C-terminal region corresponding to the loss of approximately 12 AA residues from the C-terminus. Succinylated at Lys-287 and Lys-1291. Desuccinylated at Lys-1291 by SIRT5, leading to activation. Glutarylated. Glutarylation levels increase during fasting. Deglutarylated by SIRT5 at Lys-55, Lys-219, Lys-412, Lys-889, Lys-892, Lys-915, Lys-1360 and Lys-1486, leading to activation. |
| Function | Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell. |
| Protein Name | Carbamoyl-Phosphate Synthase Ammonia - MitochondrialCarbamoyl-Phosphate Synthetase ICpsase I |
| Database Links | Reactome: R-HSA-70635 |
| Cellular Localisation | MitochondrionNucleusNucleolusCell MembranePeripheral Membrane ProteinExtracellular SideLocalizes To The Cell Surface Of Hepatocytes |
| Alternative Antibody Names | Anti-Carbamoyl-Phosphate Synthase Ammonia - Mitochondrial antibodyAnti-Carbamoyl-Phosphate Synthetase I antibodyAnti-Cpsase I antibodyAnti-CPS1 antibody |
Information sourced from Uniprot.org