Anti-CPS1 antibody (820-930) (STJ11104303)

Name: Anti-CPS1 antibody (820-930) (STJ11104303)
SKU: STJ11104303
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11104303

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Short Description	Rabbit polyclonal Carbamoyl-Phosphate Synthase Ammonia-Mitochondrial (820-930) antibody for use in WB, IF, ICC and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:100-1:500 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	CPS1
Gene ID	1373
Uniprot ID	CPSM_HUMAN
Immunogen Region	820-930
Immunogen Sequence	RMCHPSIEGFTPRLPMNKEW PSNLDLRKELSEPSSTRIYA IAKAIDDNMSLDEIEKLTYI DKWFLYKMRDILNMEKTLKG LNSESMTEETLKRAKEIGFS DKQISKCLGLT
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 820-930 of human CPS1 (NP_001116105.1).

Tissue Specificity	Primarily in the liver and small intestine.
Post Translational Modifications	Undergoes proteolytic cleavage in the C-terminal region corresponding to the loss of approximately 12 AA residues from the C-terminus. Succinylated at Lys-287 and Lys-1291. Desuccinylated at Lys-1291 by SIRT5, leading to activation. Glutarylated. Glutarylation levels increase during fasting. Deglutarylated by SIRT5 at Lys-55, Lys-219, Lys-412, Lys-889, Lys-892, Lys-915, Lys-1360 and Lys-1486, leading to activation.
Function	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
Protein Name	Carbamoyl-Phosphate Synthase Ammonia - Mitochondrial Carbamoyl-Phosphate Synthetase I Cpsase I
Database Links	Reactome: R-HSA-70635
Cellular Localisation	Mitochondrion Nucleus Nucleolus Cell Membrane Peripheral Membrane Protein Extracellular Side Localizes To The Cell Surface Of Hepatocytes
Alternative Antibody Names	Anti-Carbamoyl-Phosphate Synthase Ammonia - Mitochondrial antibody Anti-Carbamoyl-Phosphate Synthetase I antibody Anti-Cpsase I antibody Anti-CPS1 antibody

Information sourced from Uniprot.org