Anti-CPEB4 antibody (667-717 aa) (STJ197877)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CPEB4 at the amino acid range 667-717
General Information
| Short Description | Rabbit polyclonal anti-Cytoplasmic polyadenylation element-binding protein 4 (667-717 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CPEB4 |
| Gene ID | 80315 |
| Uniprot ID | CPEB4_HUMAN |
| Immunogen | Synthesized peptide derived from the human CPEB4 at the amino acid range 667-717 |
| Immunogen Region | 667-717 aa |
| Specificity | This antibody detects endogenous levels of human CPEB4 |
Additional Info
| Function | Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE-regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation. Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT. Stimulates proliferation of melanocytes. In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory. |
| Protein Name | Cytoplasmic Polyadenylation Element-Binding Protein 4Cpe-Bp4Cpe-Binding Protein 4Hcpeb-4 |
| Database Links | |
| Cellular Localisation | CytoplasmCell ProjectionDendriteDendritic SpinePostsynaptic DensityAxonGrowth ConeEndoplasmic ReticulumPerinuclear Region |
| Alternative Antibody Names | Anti-Cytoplasmic Polyadenylation Element-Binding Protein 4 antibodyAnti-Cpe-Bp4 antibodyAnti-Cpe-Binding Protein 4 antibodyAnti-Hcpeb-4 antibodyAnti-CPEB4 antibodyAnti-KIAA1673 antibody |
Information sourced from Uniprot.org