Anti-COX15 antibody (181-230 aa) (STJ92435)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human COX15 at the amino acid range 181-230
General Information
| Short Description | Rabbit polyclonal anti-Cytochrome c oxidase assembly protein COX15 homolog (181-230 aa) for use in IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COX15 |
| Gene ID | 1355 |
| Uniprot ID | COX15_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human COX15 at the amino acid range 181-230 |
| Immunogen Region | 181-230 aa |
| Specificity | COX15 Polyclonal Antibody detects endogenous levels of COX15 protein. |
Additional Info
| Function | Catalyzes the second reaction in the biosynthesis of heme A, a prosthetic group of mitochondrial cytochrome c oxidase (CcO). Heme A is synthesized from heme B by two sequential enzymatic reactions catalyzed by heme O synthase (HOS) and heme A synthase (HAS). HAS catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8, in a reaction that involves matrix ferredoxin and ferredoxin reductase. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A. |
| Protein Name | Heme A Synthase Cox15HasCytochrome C Oxidase Assembly Protein Cox15 Homolog |
| Database Links | Reactome: R-HSA-189451Reactome: R-HSA-9864848 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Heme A Synthase Cox15 antibodyAnti-Has antibodyAnti-Cytochrome C Oxidase Assembly Protein Cox15 Homolog antibodyAnti-COX15 antibody |
Information sourced from Uniprot.org