Anti-Coronin 1a antibody (STJA0040588)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenSynthetic peptide
General Information
| Short Description | Chicken polyclonal anti-Coronin 1a for use in IHC, ICC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ICC/WB |
| Host | Chicken |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Concentration | 100 µg/mL |
| Purification | Affinity-Purified IgY |
| Dilution Range | WB 1:5000-1:10000IHC 1:1000-1:2000ICC 1:1000-1:2000 |
| Formulation | Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (“PBS, pH 7.2) with sodium azide (0.02%, w/v) added as a preservative." |
| Storage Instruction | Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody. |
Target Information
| Gene Symbol | CORO1A |
| Gene ID | 11151 |
| Uniprot ID | COR1A_HUMAN |
| Immunogen | Synthetic peptide |
| Immunogen Sequence | Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin. Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation. |
| Function | May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. |
| Protein Name | Coronin-1aCoronin-Like Protein AClipin-ACoronin-Like Protein P57Tryptophan Aspartate-Containing Coat ProteinTaco |
| Database Links | Reactome: R-HSA-9636383 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexCytoplasmic VesiclePhagosome MembraneIn Non-Infected MacrophagesAssociated With The Cortical Microtubule NetworkIn Mycobacteria-Infected MacrophagesBecomes Progressively Relocalized And Retained Around The Mycobacterial PhagosomesRetention On The Phagosomal Membrane Is Strictly Dependent On Mycobacterial Viability And Not Due To Impaired Acidification |
| Alternative Antibody Names | Anti-Coronin-1a antibodyAnti-Coronin-Like Protein A antibodyAnti-Clipin-A antibodyAnti-Coronin-Like Protein P57 antibodyAnti-Tryptophan Aspartate-Containing Coat Protein antibodyAnti-Taco antibodyAnti-CORO1A antibodyAnti-CORO1 antibody |
Information sourced from Uniprot.org