| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CORIN (1-110) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CORIN |
| Gene ID: |
10699 |
| Uniprot ID: |
CORIN_HUMAN |
| Immunogen Region: |
1-110 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human CORIN (NP_006578.2). |
| Immunogen Sequence: |
MKQSPALAPEERCRRAGSPK PVLRADDNNMGNGCSQKLAT ANLLRFLLLVLIPCICALVL LLVILLSYVGTLQKVYFKSN GSEPLVTDGEIQGSDVILTN TIYNQSTVVS |
| Tissue Specificity | Highly expressed in heart. Expressed in heart myocytes. Also expressed in pregnant uterus. Detected in blood, in plasma as well as in serum (at protein level). |
| Post Translational Modifications | N-glycosylated.required for processing and activation. Activated through proteolytic processing by a trypsin-like protease.cleaved into a N-terminal propeptide and an activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while 160 kDa and 100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1. A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments). |
| Function | Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing. Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. Isoform 2: Has weaker endopeptidase activity compared to isoform 1. |
| Protein Name | Atrial Natriuretic Peptide-Converting EnzymeCorinHeart-Specific Serine Proteinase Atc2Pro-Anp-Converting EnzymeTransmembrane Protease Serine 10 Cleaved Into - Atrial Natriuretic Peptide-Converting Enzyme - N-Terminal Propeptide - Atrial Natriuretic Peptide-Converting Enzyme - Activated Protease Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 180 Kda Soluble Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 160 Kda Soluble Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 100 Kda Soluble Fragment |
| Database Links | Reactome: R-HSA-5578768 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinMay Easily Detached From The Endothelial Cell MembraneIsoform 2: Cell MembraneLess Efficiently Targeted To The Cell Membrane Compared To Isoform 1Atrial Natriuretic Peptide-Converting Enzyme180 Kda Soluble Fragment: SecretedSoluble Form Produced Following Cleavage By Adam10160 Kda Soluble Fragment: SecretedSoluble Form Produced Following Autocatalytic Cleavage100 Kda Soluble Fragment: Secreted |
| Alternative Antibody Names | Anti-Atrial Natriuretic Peptide-Converting Enzyme antibodyAnti-Corin antibodyAnti-Heart-Specific Serine Proteinase Atc2 antibodyAnti-Pro-Anp-Converting Enzyme antibodyAnti-Transmembrane Protease Serine 10 Cleaved Into - Atrial Natriuretic Peptide-Converting Enzyme - N-Terminal Propeptide - Atrial Natriuretic Peptide-Converting Enzyme - Activated Protease Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 180 Kda Soluble Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 160 Kda Soluble Fragment - Atrial Natriuretic Peptide-Converting Enzyme - 100 Kda Soluble Fragment antibodyAnti-CORIN antibodyAnti-CRN antibodyAnti-TMPRSS10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
