Anti-COQ3 antibody (50-369) (STJ29605)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal COQ3 (50-369) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COQ3 |
| Gene ID | 51805 |
| Uniprot ID | COQ3_HUMAN |
| Immunogen Region | 50-369 |
| Immunogen Sequence | PGVFNEYRTIWFKSYRTIFS CLNRIKSFRYPWARLYSTSQ TTVDSGEVKTFLALAHKWWD EQGVYAPLHSMNDLRVPFIR DNLLKTIPNHQPGKPLLGMK ILDVGCGGGLLTEPLGRLGA SVIGIDPVDENIKTAQCHKS FDPVLDKRIEYRVCSLEEIV EETAETFDAVVASEVVEHVI DLETFLQCCCQVLKPGGSLF ITTINKTQLSYALGIVFSEQ IASIVPKGTHTWEKFVSPE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 50-369 of human COQ3 (NP_059117.3). |
Additional Info
| Function | O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10. |
| Protein Name | Ubiquinone Biosynthesis O-Methyltransferase - Mitochondrial3-Demethylubiquinol 3-O-Methyltransferase3-Demethylubiquinone 3-O-MethyltransferasePolyprenyldihydroxybenzoate Methyltransferase |
| Database Links | Reactome: R-HSA-2142789 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Antibody Names | Anti-Ubiquinone Biosynthesis O-Methyltransferase - Mitochondrial antibodyAnti-3-Demethylubiquinol 3-O-Methyltransferase antibodyAnti-3-Demethylubiquinone 3-O-Methyltransferase antibodyAnti-Polyprenyldihydroxybenzoate Methyltransferase antibodyAnti-COQ3 antibodyAnti-UG0215E05 antibody |
Information sourced from Uniprot.org