| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Protein Name | Cop9 Signalosome Complex Subunit 8Sgn8Signalosome Subunit 8Cop9 HomologHcop9Jab1-Containing Signalosome Subunit 8 |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 8 antibodyAnti-Sgn8 antibodyAnti-Signalosome Subunit 8 antibodyAnti-Cop9 Homolog antibodyAnti-Hcop9 antibodyAnti-Jab1-Containing Signalosome Subunit 8 antibodyAnti-COPS8 antibodyAnti-CSN8 antibody |
Information sourced from Uniprot.org
