Anti-COPS7A antibody (1-275) (STJ110511)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal COPS7A (1-275) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | COPS7A |
| Gene ID | 50813 |
| Uniprot ID | CSN7A_HUMAN |
| Immunogen Region | 1-275 |
| Immunogen Sequence | MSAEVKVTGQNQEQFLLLAK SAKGAALATLIHQVLEAPGV YVFGELLDMPNVRELAESDF ASTFRLLTVFAYGTYADYLA EARNLPPLTEAQKNKLRHLS VVTLAAKVKCIPYAVLLEAL ALRNVRQLEDLVIEAVYADV LRGSLDQRNQRLEVDYSIGR DIQRQDLSAIARTLQEWCVG CEVVLSGIEEQVSRANQHKE QQLGLKQQIESEVANLKKTI KVTTAAAAAATSQDPEQHL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human COPS7A (NP_057403.1). |
Additional Info
| Tissue Specificity | Widely expressed. Expressed at high level in brain, heart and skeletal muscle. |
| Post Translational Modifications | Phosphorylated by CK2 and PKD kinases. |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Protein Name | Cop9 Signalosome Complex Subunit 7aSgn7aSignalosome Subunit 7aDermal Papilla-Derived Protein 10Jab1-Containing Signalosome Subunit 7a |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 7a antibodyAnti-Sgn7a antibodyAnti-Signalosome Subunit 7a antibodyAnti-Dermal Papilla-Derived Protein 10 antibodyAnti-Jab1-Containing Signalosome Subunit 7a antibodyAnti-COPS7A antibodyAnti-CSN7A antibodyAnti-DERP10 antibody |
Information sourced from Uniprot.org