| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-COPS7A (1-275) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
COPS7A |
| Gene ID: |
50813 |
| Uniprot ID: |
CSN7A_HUMAN |
| Immunogen Region: |
1-275 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human COPS7A (NP_057403.1). |
| Immunogen Sequence: |
MSAEVKVTGQNQEQFLLLAK SAKGAALATLIHQVLEAPGV YVFGELLDMPNVRELAESDF ASTFRLLTVFAYGTYADYLA EARNLPPLTEAQKNKLRHLS VVTLAAKVKCIPYAVLLEAL ALRNVRQLEDLVIEAVYADV LRGSLDQRNQRLEVDYSIGR DIQRQDLSAIARTLQEWCVG CEVVLSGIEEQVSRANQHKE QQLGLKQQIESEVANLKKTI KVTTAAAAAATSQDPEQHL |
| Tissue Specificity | Widely expressed. Expressed at high level in brain, heart and skeletal muscle. |
| Post Translational Modifications | Phosphorylated by CK2 and PKD kinases. |
| Function | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
| Protein Name | Cop9 Signalosome Complex Subunit 7aSgn7aSignalosome Subunit 7aDermal Papilla-Derived Protein 10Jab1-Containing Signalosome Subunit 7a |
| Database Links | Reactome: R-HSA-5696394Reactome: R-HSA-6781823Reactome: R-HSA-8856825Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cop9 Signalosome Complex Subunit 7a antibodyAnti-Sgn7a antibodyAnti-Signalosome Subunit 7a antibodyAnti-Dermal Papilla-Derived Protein 10 antibodyAnti-Jab1-Containing Signalosome Subunit 7a antibodyAnti-COPS7A antibodyAnti-CSN7A antibodyAnti-DERP10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
